Korean Society for Biotechnology and Bioengineering Journal Korean Society for Biotechnology and Bioengineering Journal

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Korean Society for Biotechnology and Bioengineering Journal 2011; 26(5): 433-438

Published online October 31, 2011

Copyright © Korean Society for Biotechnology and Bioengineering.

생약 조성물, DTS20의 알코올 분해 및 항염증 효과

Effect of Herbal Composition, DTS20 on Alcohol Degradation and Anti-inflammatory Activity

윤택준(유한대학 식품영양과), 조선영(경기대학교 식품생물공학과), 이수정(유한대학 식품영양과), 김은영(유한대학 식품영양과), 신광순(경기대학교 식품생물공학과), 서형주(고려대학교 식품영양학과)

Abstract

These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L., Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect, alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-${\alpha}$ in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.

Keywords: Herbal extracts, alcohol, inflammation, cytokine, NO